Spring Semester - 2018
This course provides an introduction to high-altitude biology and medicine. It focuses on mechanisms of hypoxia resistance influencing the requirement to match O2 supply and demand throughout the O2 cascade: a) gas exchange (hypoxic ventilatory responses (HVR) & morphology of lungs and air sacs), b) circulatory O2 delivery (Hb-O2 affinity, blood hemoglobin content [Hb]), hematocrit (Hct), & cardiac output), c) tissue O2 diffusion (muscle capillarity & myoglobin (Mb) function), and d) tissue energy metabolism (mitochondrial respiration & enzyme function). Lectures and discussions will draw from disciplines as diverse as genomics, integrated physiology, population genetics, biochemistry, gene expression, evolution, and alpine medicine. Taxonomic examples from the literature will include humans, other mammals, birds, herps, and fish.
Class meeting times: 5:00 to 6:15 PM Tue & Thu - Cox 166
Email and phone contacts: kevin.g.mccracken@gmail.com; +1 (786) 414-4780
Office hours: Tue & Thu before class after 2 PM or by appointment
Dropbox link for weekly readings
Dowload .pdf of syllabus



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